The immuno-pathogenesis of progressive scarring trachoma: results of a four-year longitudinal study in Tanzanian children

This study highlights the importance of innate pro-inflammatory signals from the epithelium and implicate IL -23A -responsive cells in driving trachomatous scarring, with potential key mechanistic roles for PDGFB, MMP12 and SPARCL1 in orchestrating fibrosis. 

The conjunctival transcriptome in Ethiopians after trichiasis surgery: associations with the development of eyelid contour abnormalities and the effect of oral doxycycline treatment

Surgery to correct trichiasis is a key component of the World Health Organisation trachoma elimination strategy, however unfavourable outcomes such as eyelid contour abnormalities (ECA) following surgery are relatively common. This study aimed to understand the transcriptional changes associated with the early development of ECA and the impact of doxycycline, which has anti-inflammatory and anti-fibrotic properties, upon these transcription patterns.

Posterior lamellar versus bilamellar tarsal rotation surgery for trachomatous trichiasis: Long-term outcomes from a randomised controlled trial

This study examined the participants of a clinical trial four years after enrolment to identify which of the two most commonly used eyelid surgery procedures to treat trachomatous trichiasis, the posterior Lamellar Tarsal Rotation (PLTR) and Billamelar Tarsal Rotation (BLTR), gives better results in the long-term.

Photographing Eyelids Before and After Trachomatous Trichiasis (TT) Surgery: A Resource Package (French)

This package highlights the use of photo taking before and after trichiasis surgery to help surgeons, technical supervisors, and national programs improve TT surgical quality. Contents include how to photograph eyelids and how the photos can support surgeon skill strengthening.

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